Together, we're advancing not just a product, but an entire field.
Renal Denervation (RDN) treatment has its roots in surgical sympathectomy techniques dating back to the 1930s. However, this new technology represents the first time that physicians have been able to target renal nerves specifically via a catheter-based intervention.
This endovascular approach opens the door to better understanding the relationship between sympathetic hyperactivity and hypertension. Medtronic remains committed to publishing the results of our research so that as we learn, everyone learns.
To learn more about our research, see the publications and resources listed below:
Sympathetic Hyperactivity & Hypertension
Siddiqi L, Joles JA, Grassi G, Blankestijn PJ. Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system? J Hypertens. 2009 Jul;27(7):1341-9.
Augustyniak RA, Tuncel M, Zhang W, Toto RD, Victor RG. Sympathetic overactivity as a cause of hypertension in chronic renal failure. J Hypertens. 2002;20(1):3-9.
DiBona GF. Sympathetic nervous system and the kidney in hypertension. Curr Opin Nephrol Hypertens. 2002;11(2):197-200.
Mancia G, Grassi G, Giannattasio C, Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension. 1999;34(4 Pt 2):724-728.
Hypertension Guidelines & Statistics
Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, et al. Heart disease and stroke statistics--2010 update: a report from the american heart association. Circulation. 2010;121(7):e46-e215.
Cutler JA, Sorlie PD, Wolz M, Thom T, Fields LE, Roccella EJ. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004. Hypertension. 2008;52(5):818-827.
Sarafidis PA, Bakris GL. Resistant Hypertension: An Overview of Evaluation and Treatment. Journal of the American College of Cardiology. 2008;52(22):1749-57.
Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the ESC. Eur Heart J. 2007;28(12):1462-1536.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr., et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-1252.
